Another remarkable, recurrent feature of the integrative explanations that I have targeted in this book is their regular appeal to non-epistemic, social, or ethical values. This makes those explanations, and, by extension, integrative promise, a fruitful site for philosophical study of the role of non-epistemic values in science. In this chapter, I explore this connection by looking at the invocation of so-called “grand challenges” in these explanations. Integrative work is often taken to be essential to the resolution of large-scale, difficult social and cultural problems. To illuminate this relationship, I’ll consider a recent programmatic document describing future research for the European Molecular Biology Laboratory (EMBL). They consistently link the stakes of the most integrative parts of their program to the resolution of grand challenges, and thus to social and ethical value commitments.