As part of the Holistic Psychosocial Care, this chapter explores the integral role of spirituality in supporting individuals facing end-of-life and grief, recognizing that the search for meaning is both a personal and collective process. Drawing from psychological, sociological, and anthropological perspectives, it acknowledges how spiritual and religious practices provide personal solace while also offering social frameworks for understanding loss and suffering. This chapter introduces spiritual assessment tools and highlights the importance of a human-centered, culturally sensitive approach to spiritual care. Mindfulness practices, such as mindful breathing and tasting, guided visualization, and uninhibited dancing, are central to the holistic support discussed. These techniques, applicable in both individual and group settings, help foster resilience, emotional balance, and a sense of peace. Research supports their effectiveness in improving psychological and physical well-being. In addition, this chapter underscores the importance of communal rituals and collective spiritual practices in providing emotional and social support. Whether used individually or in group contexts, these practices help connect people to broader cultural and spiritual frameworks, facilitating healing and growth. By integrating spiritual assessments, mindfulness techniques, and therapeutic interventions, this chapter offers a thoughtful discussion of spirituality as a source of support for individual and collective loss.