The social determinants of health (SDoH) have long been recognized as critical factors in understanding health outcomes across populations. This chapter explores the integration of trauma-informed principles within a health geography framework, emphasizing the need to “re-root” SDoH within spatial, socioecological, and fundamental causes perspectives. Through a historical overview of health geography, this work underscores the importance of place and spatial analysis in examining health disparities. It critiques the simplification of current SDoH frameworks and advocates for more nuanced models that incorporate the complexities of human-environment interactions, particularly in addressing health inequities rooted in historical and collective traumas. By incorporating trauma-informed approaches, the chapter highlights the necessity of prioritizing safety, trustworthiness, and empowerment in public health research and practice.