This chapter explores the history of the Interstate Highway System, its impact on minoritized communities, and potential policy changes to improve health and living conditions. Using a social determinants of health lens, the chapter describes how interstate routes directly and deliberately targeted minority communities, effectively functioning as an extension of segregationist policies. The implications for health and well-being are discussed, focusing on both direct pollutant exposures and the destruction of many previously thriving minoritized communities. Furthermore, the chapter investigates interstate removal projects, emphasizing the need for a paradigm shift in transportation planning to equity-focused interventions to ensure community stability.