The places in which individuals live, work, and play significantly affect their health, and unequal exposures lead to health inequalities. However, social-spatial exposures are experienced differently depending on the characteristics of the individual, the context of the place, and the time of the exposure. We introduce the concept of relative vulnerable time of exposures, which can lead to differential health outcomes by altering the quality or magnitude of the exposure itself or by affecting the pathway from the exposure to amplify adverse health outcomes. We illustrate this concept with qualitative research on geographic mobility and health among Black and Hispanic sexual minority men.