This book provides a comprehensive exploration of Social and Structural Determinants of Health (SSDoH) through a multidisciplinary lens. It addresses the integration of SSDoH concepts into practice, such as electronic health records, and examines their impacts on various subgroups. The volume includes well-conceived case studies that are empirically, methodologically, and theoretically grounded. By fostering interdisciplinary discussions, it challenges researchers to deepen their understanding of health mechanisms across space and time. This book is a vital resource for policymakers, practitioners, and scholars, aiming to enhance community health, well-being, and equity globally. It also serves as a complementary reader for related academic courses.