Since the discovery of Ti mass-independent and mass-dependent variations in meteorites and in terrestrial rocks and minerals, Ti isotopes have become a powerful tool for tracing isotope anomalies in solar system materials and fractionation processes in differentiated bodies. In particular, mass-dependent fractionations have recently proven useful in a variety of high temperature applications including magmatic differentiation of the Earth’s mantle, the evolution of the continental crust, as well as mineral resources. These applications are made possible by continued advances in mass spectrometry, in addition to continued development of techniques for solution and in-situ measurements. In this chapter we review the state-of-the-art approaches for the measurement of mass-dependent Ti isotope variations, and provide a brief synopsis and relevant references to their geochemical applications.