The worldwide decline of catch fisheries and the simultaneous increase in the world’s population and demand for seafood highlight how important aquaculture is to meeting future seafood demands in the face of rapid climate change. However, the industry’s reliance on ecosystem services and ambient climatic conditions highlights how susceptible it is to stressors brought on by climate change. This chapter examines methods for improving inland aquaculture systems’ resilience using a multidisciplinary approach, emphasizing biological adaptations, engineering, and management. Essential strategies include digital transformation, environmental restrictions to reduce stressor exposure, and epigenetic adaptations brought about by exposures during early life stages or from parents. It is stressed that predictive modeling and real-time monitoring of biological and environmental responses are crucial components of adaptive management. Examined is how diet quality can help fulfill rising energy needs, emphasizing how it might mitigate biotic and abiotic stressors. The chapter also emphasizes the value of farm-level observations and long-term empirical research in guiding region-specific adaptation strategies. In order to move aquaculture from temporary coping strategies to long-term, climate-resilient operations, governance frameworks that incorporate necessary changes are required. The study concludes that inland aquaculture’s sustainability and adaptability in a changing environment depend on interdisciplinary cooperation, informed policymaking, and technical innovation.