The skeletal muscle is one of the most plastic organs in our body. It readily responds to increased physical activity, and inactivity, and as the largest organ in the body, it plays a crucial role in the regulation of all major metabolic events in the body. Due to the great adaptability, skeletal muscles process well-described dose response, and this chapter deals with the unique and universal nature of this response. The activation of satellite cells via different exercise-associated agents, like lactate, nitric oxide, or 8-oxoG-OGG1 complex, has a great impact of the adaptability of skeletal muscle. The trainability of skeletal muscle is also discussed in this chapter.