Available donor skin is often insufficient for extensive burn cases, where thin meshed split-thickness skin graftsSplit-thickness skin grafts (STSG) or cultured epidermal autografts are typically used to close wounds. However, meshed STSGs can result in poor cosmetic outcomes due to insufficient dermal beds, while cultured epidermal autografts face challenges with graft survival. To address these limitations, several dermal substitutes have been developed. Among them, acellularAcellular matrixAllogeneic dermal matrix (ADM)ADMAllogeneic dermal matrix allogenic dermal matrix (AADM), produced by decellularizing allogenic cadaver skin, closely resembles the physiological properties of normal human dermis (Livesey SA et al., Transplantation 60:1–9, 1995; Takami Y et al., Burns 22:182–190, 1996). This study investigates AADM’s application for 2 purposes in burn surgery: first, as a simultaneous skin graftSkin graft overlay on full-thickness burn wounds (Takami Y et al., Jpn J Burn Injuries 26:261–267, 2000), and second, as a scaffoldScaffold for a tissue-engineered autologous skin equivalent (TESETissue-engineered autologous skin equivalent (TESE)TESETissue-engineered autologous skin equivalent) (Takami Y et al., Jpn J Plast Reconstr Surg 47:867–873, 2004; Am J Transplant 82(Suppl 3):746, 2006).