Treatment of burn wounds is challenging among pediatric patients for several reasons, among them being thin skin, limited area for graft donor sites, and the increased propensity for hypertrophic scarring. These challenges become more difficult the deeper and more complex the burn injury. Dermal skin substitutes and regenerative templates, specifically Integra® and Novosorb® Biodegradable Temporizing Matrix, help mitigate these challenges and have proven especially beneficial in treating full-thickness burns within the pediatric population.