Echocardiographic imaging is crucial for the diagnostic, prognostic and therapeutic assessment of unexplained heart failure or clinically suspected cardiac amyloidosis (CA) patients. Echocardiographic imaging in CA should include cardiac morphology as well as a comprehensive assessment of systolic and diastolic function including strain imaging and hemodynamic assessment of filling pressures. Important echocardiographic findings in CA include thickening of the left ventricular walls as well as thickening of other cardiac structures. Reduced systolic function is frequently noted in CA even in the presence of normal ejection function and more advanced techniques such as global longitudinal strain are necessary to accurately assess systolic function in these patients. CA causes a broad spectrum of diastolic dysfunction (DD) with more severe DD manifesting later in the disease course. Tissue Doppler diastolic annular velocities are reduced and an elevated high E:e′ reflecting increased LV filling pressures is commonly seen in CA.