Scholarlink

Following decades of experiments in animal models, the world’s first genetically modified pig-to-human heart transplant took place in January 2022. In this chapter, we will discuss several considerations and challenges in xenotransplantation, including anatomic and physiologic differences between pig and human hearts: immunological response and rejection, organ overgrowth, infections, and ethical dilemmas. We also describe the clinical course of the first genetically modified heart xenotransplant.

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Xenotransplantation

  • 章节

  • 发表日期：

    2025年

查看全文
  • Emily Newman,
  • Indranee Rajapreyar,
  • Yevgeniy Brailovsky,
  • Howard J. Eisen

摘要

Following decades of experiments in animal models, the world’s first genetically modified pig-to-human heart transplant took place in January 2022. In this chapter, we will discuss several considerations and challenges in xenotransplantation, including anatomic and physiologic differences between pig and human hearts: immunological response and rejection, organ overgrowth, infections, and ethical dilemmas. We also describe the clinical course of the first genetically modified heart xenotransplant.