I present a modern Humean Argument from Animal Welfare. The argument takes as its “data” facts about animal welfare—good and bad facts involving animals. It maintains that a rival to Theism—namely, the “Hypothesis of Indifference”—much better explains those facts than Theism, thereby giving us a strong reason for rejecting Theism. After explaining how Humean Arguments from Evil work, I explain a Humean Argument from Animal Welfare. I indicate two potential strengths of the argument that distinguish it from other Arguments from Evil. And I conclude by considering a range of objections to the argument. My overall aim is not to conclusively defend or reject the argument but to indicate the strengths and weaknesses of a Humean Argument from Animal Welfare.