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You will be introduced to autophagy/mitophagy machinery in the heart, including the key proteins and regulators of the process. Next you’ll learn about the stressors that can invoke autophagy/mitophagy, especially those relevant to the heart. The next section will cover methodology for studying autophagy, including biochemical approaches as well as microscopy. Additional methods for studying autophagy and autophagic flux in cells and mice will be presented. Finally, this chapter includes a discussion on the role of autophagy in the context of heart disease.

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The Role of Autophagy and Mitophagy in Cardiomyocyte Ischemic Injury

  • 章节

  • 发表日期：

    2025年

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  • Roberta A. Gottlieb,
  • Somayeh Pourpirali

摘要

You will be introduced to autophagy/mitophagy machinery in the heart, including the key proteins and regulators of the process. Next you’ll learn about the stressors that can invoke autophagy/mitophagy, especially those relevant to the heart. The next section will cover methodology for studying autophagy, including biochemical approaches as well as microscopy. Additional methods for studying autophagy and autophagic flux in cells and mice will be presented. Finally, this chapter includes a discussion on the role of autophagy in the context of heart disease.