Guns are potent weapons, expertly designed for destruction and killing. They are also powerful symbols, part of the culture where they are known and used—specifically, the gun culture—loaded with gendered, racial, national, and historic meaning. At the same time, they are material objects that interact with the minds, bodies, and emotions of owners and users. This chapter offers an anthropological perspective on the meaning and materiality of guns, arguing that meaning to a substantial extent is the material quality of objects and how those objects operate on and transform the subjectivity of owners/users. Taking a cue from network and assemblage theorists like Latour and Gell, the chapter explores how a person with a gun becomes a new entity or agent, more than a person alone or a gun alone. The chapter presents case studies from several parts of the world—Haiti, Africa (Uganda and the Gambia), the Middle East (Lebanon and Israel), and of course the United States—that illustrate the point that gun owners/users acquire new skills, new affects, and new visceral sensibilities (a new “habitus,” to borrow Bourdieu’s term) which, along with the discursive messages and behavioral scripts in the culture, constitute the meaning of guns.