This chapter delves into the complexities surrounding cannabis use, its impact on youth, and the necessary steps for translating scientific findings into public policy. It begins with a focus on the challenges and solutions related to youth cannabis use, including its psychiatric symptoms and the implications for sexual and gender minority (SGM) youth. The chapter further examines cognitive effects in adolescents and young adults, highlighting studies on regular cannabis consumers and early cannabis use in individuals with developmental brain disorders. A critical analysis is provided on the cognitive and behavioral effects of cannabis, with insights into how early use can contribute to long-term neurodevelopmental issues. The chapter discusses the need for educational empowerment among teens, parents, and healthcare providers to foster informed dialogues about cannabis use. It also explores the impact of cannabis on families, including the use of purified cannabidiol (CBD) in pediatric epilepsy, and the risks associated with secondhand cannabis smoke exposure, particularly regarding physical and neurobehavioral health in youth. The chapter further discusses cannabis use during pregnancy, its effects on reproductive health, and the development of the brain via the endocannabinoid system. A final emphasis is placed on the role of research, including twin studies, to address residual confounding and better understand cannabis’s effects on brain and behavior. In conclusion, the chapter advocates for comprehensive policy reform to ensure the health and safety of youth in the context of cannabis legalization and use.