Large hydropower projects in the high mountainous and canyon regions of western China often encounter toppling slopes presenting significant challenges such as controlling large deformations, managing substantial movements caused by minor disturbances, and handling complex construction conditions. During blasting excavation, the vibration mechanism of toppling slopes with a layered structure differs markedly from that of conventional rock slopes, lead to distinctive dynamic responses. Consequently, establishing safety control standards related to slope stability is a critical research focus for such topping slopes. This paper examines these challenges at the Miaowei Hydropower Station on the Lancang River. By analyzing blasting vibration monitoring results collected during construction period, along with rockmass structure assessments, provides a comprehensive analysis of the blasting vibration mechanism from the perspectives of blasting excavation dynamics, excavation procedure, slope morphology, and rock mass discontinuity characteristics. Additionally, based on discrete element numerical methods for dynamic analysis, a feedback analysis of the slope blasting excavation process was conducted, leading to the proposal safety control standards based on two key parameters: blasting excavation charge and particle vibration velocity. Specifically, the single-shot charge should not exceed 30 kg, the total charge for per blast should not exceed 600 kg, and the particle velocity of the blasting vibration should not exceed 4 cm/s.