Despite a documented decline in conventional cigarette smoking ((CDC, Health effects of cigarette smoking. Centers for Disease Control and Prevention, 2021)) there has been a surge in electronic cigarette (e-cigarette) use (Surgeon General’s report, 2016). Approximately half of current e-cigarette users reported never being conventional cigarette smokers (King et al., 2013), underscoring the necessity of comprehending both conventional and e-cigarette usage patterns distinctively. While examining smoking patterns and disparities in the risk of conventional cigarette smoking across different population groups is crucial, equal attention must be given to understanding smoking cessation patterns. Using an intersectional framework, we generated exploratory statistics to examine smoking behavior and cessation patterns across sexuality and gender identity. Using three sets of multi-year data (2016–2021) from the Behavioral Risk Factor Surveillance System (BRFSS), we highlight three key findings. First, our data indicate that sexual minorities exhibit higher percentages of both e-cigarette and conventional cigarette usage. Second, we find evidence of high percentages of smoking cessation attempts regardless of sexual identity for both conventional and e-cigarettes. Finally, in our sample we find that regardless of sexual identity, e-cigarette smokers were younger, male, and economically disadvantaged. We also find evidence of more casual e-cigarette use across sexual identity. More work should examine additional factors that are significant predictors of e-cigarette use.