The COVID-19 pandemic has introduced significant challenges in dermatology, particularly affecting skin health and the management of conditions like acne. Cutaneous manifestations associated with COVID-19, ranging from rashes to vasculitic events, have emerged as important diagnostic indicators, with some appearing early in the disease’s course. These skin conditions have driven the need for ongoing research into their mechanisms and clinical significance. Concurrently, the pandemic has reshaped dermatological care, with a shift toward telemedicine to address rising concerns about virus transmission and restricted access to in-person healthcare. This shift, while effective for some, poses challenges in managing more complex skin conditions. The mental health toll on both practitioners and patients further complicates care delivery, with stress and anxiety exacerbating skin disorders like acne. Acne, particularly during the pandemic, has worsened due to heightened stress levels, disrupted skincare routines, and the frequent use of face masks, leading to a condition known as “maskne.” The pathophysiology of acne involves a complex interplay of hormonal, microbial, and genetic factors, with stress-related hormonal changes driving increased sebum production. Treatments for acne exacerbations during the pandemic combine traditional topical and systemic therapies with psychological interventions, such as cognitive behavioral therapy. The importance of teledermatology has grown, allowing continued care, but cannot fully replace in-person consultations for severe cases. Addressing both the physical and psychological dimensions of acne management, alongside lifestyle modifications, is critical to improving patient outcomes during these unprecedented times.