Glycans are not only structural molecules but also take part in cell proliferation, differentiation, morphogenesis, inflammation, and regeneration processes. As a biological cue signaling molecules glycans would modulate the adhesion and differentiation of cells. Composites become a novel approach for the functionalization of biomaterials with glycans. The specific affinity of glycans onto biological receptors would also be used in targeting drug carriers. The so called bioorthogonal reactions impart high biocompatibility in formulation of injectable gels and self-healing gels, and biological glues. Polysaccharides and their derivatives are taking attention in 3D bioprinting applications and the formulation of bioinks due to biocompatibility and biodegradability. For tissue engineering applications, composite formation and surface coating with glycans are accepted strategies in production of mechanically stable yet bioactive scaffolds. Glycans blends would also be presented as potential composites via interpenetrating macromolecules chains. Mucilage is a class of glycan polysaccharide that composed of arabinoxylan and rhamnogalacturonan, which is used due to its interesting viscous-sticky properties. Hydrogels of mucilage have potential to encapsulate cells under physiological crosslinking conditions. Furthermore, glycan polysaccharides find application in drug delivery systems, including nano carriers, microcapsules, pH-responsive systems, oral drug delivery, and systems designed for the targeted delivery of toxic anti-cancer drugs.