Muscle, the largest organ in the human body, plays pivotal roles in posture, movement, and internal functions. Despite its inherent regenerative capacity, extensive damage surpasses self-repair capabilities. Understanding various muscle disorders, current rehabilitation approaches, and the intricacies of muscle tissue repair is crucial for addressing prevalent challenges. This chapter provides a comprehensive overview of these topics, emphasizing the complex organizational structure of muscle tissue and the difficulties in devising effective treatment modalities. Notably, tissue engineering emerges as a promising strategy for addressing muscle injuries, leveraging bioinspired cues for biomimetic scaffold design. Material selection, guided by previous research findings, is pivotal in achieving biomimetic muscle tissue. Furthermore, advanced scaffold fabrication techniques offer precise control over structure, facilitating the creation of bio-mimicking architectures. This synthesis aims to inform future endeavors in designing muscle biomimetic structures, contributing to enhanced therapeutic outcomes.