The aim of this chapter is to provide a comprehensive overview of the concept and historical development of bioinspired and biomimetic regenerative medicine. This includes, at first, going through the fundamental definitions and scope of regenerative medicine, following its historical progression, and exploring its crucial role in addressing numerous health conditions. Secondly, it seeks to show how nature’s capabilities have inspired innovative approaches to facilitate the body’s recovery processes. It also explains the emergence and significance of bioinspired and biomimetic approaches within the realm of regenerative medicine by examining the positive impact of animals and natural processes on strategies for tissue/organ repair and regeneration. Besides, it investigates the integration of scientific and engineering principles in these accomplishments. The chapter highlights the potential applications of bioinspired and biomimetic regenerative medicine. Lastly, the chapter will shed light on the current research attempts in bioinspired and biomimetic regenerative medicine and offer a glimpse into the emerging trends in this field. In summary, this chapter seeks to offer a full comprehension of regenerative medicine, serving as a basic resource for readers looking to understand the concept, historical context, and promising potential of bioinspired and biomimetic regenerative medicine to shape the future of healthcare.