Numerous investigations have been conducted on the behavior of composite concrete and steel columns. However, more information is needed about the performance of structural systems incorporating these members when subjected to subductive earthquakes. Considering that several Latin American countries adopt the criteria of North American regulations, which are primarily calibrated for cortical-origin earthquakes, and considering that the response of a structural system depends on the characteristics of the earthquake to which it is subjected, it is crucial to study how these systems behave under subductive earthquakes. Previous research has determined that the probability of structural collapse during cortical earthquakes increases when analyzed under subductive earthquakes. This study examines the behavior of unique moment frames under subductive tectonic regime earthquakes, characteristic of the Pacific Ring of Fire. The research analyzes 3, 6, and 13-story planar frames with steel reinforced concrete (SRC) columns and rectangular concrete-filled steel tube (RCFT) columns, designed according to the current provisions of ANSI/AISC and ASCE/SEI 7. These frames were subjected to nonlinear time-history analysis in OpenSees, using 11 subductive seismic records from Japan, Chile, and Ecuador, scaled to the target spectrum for the maximum considered earthquake (MCER) through spectral matching. The responses of both structural systems are presented and compared. Both structural systems show inelastic story drifts of less than 50% of the limit value. Systems with RCFT exhibit higher demand/capacity rotation ratios in beams and columns than systems with SRC. In all the analyzed cases, the columns on the bottom stories are the ones that concentrated the most inelasticity. Finally, it is verified that North American standards’ design parameters and acceptance criteria are applicable in Latin American countries, which predominantly experience subductive earthquakes.