The Anti-Atlas region is situated on the northern boundary of the West African Craton (WAC). Bou Azzer massif, which comprises Precambrian inliers of the Anti-Atlas region characterized by Pan-African ophiolite, is renowned for its cobalt–nickel-arsenides veins that have been exploited since 1923 by CTT Mine of Bou Azzer. This mineralization occurs in and around serpentinized peridotites intruded by syn-tectonic quartz diorite. This study presents new data on nickel mineralization in Inguijem-Ahmane serpentinite in Bou Azzer's ophiolite and associated Co–As–Ag and Au. Despite their large outcrops, these occurrences have been little explored before, while the veins of Co–Ni–As are much better documented. Our fieldwork, petrographic study, and geochemical data, collected from Ait Ahmane serpentinite soil samples in recent studies by CTT Bou Azzer mine, provide new information on the distribution of transition and precious metals within Inguijem-Ahmane serpentinite massif. We observed gold in 1098 soil samples, with the most notable anomalies mainly located in the primary fault zones, within the talcified, carbonated, and listvenited serpentinite, and their tectonic contact of Inguijem-Ait Ahmane massive. A strong correlation exists between Co, Ni, As, and Ag. During metamorphism and metasomatism, Ni, Co, As, Au, and Ag were remobilized and deposited in faults and serpentinite borders, in the talcified, carbonated, and listvenited serpentinite and carbonate shell. The initial magmatic mineralization has been remobilized and concentrated within polytectonic structures within serpentinite.