Trauma-informed care is a critical component of nursing practice across various healthcare settings, including high-acuity, ambulatory and community environments. The definition of trauma varies across disciplines and populations, with the Substance Abuse and Mental Health Services Administration (SAMHSA) providing a widely recognized framework that emphasizes the lasting impact trauma can have on an individual’s mental, physical, social, emotional and spiritual well-being. This chapter examines the different settings in which nurses may encounter patients with a history of trauma, such as emergency departments, inpatient mental health units, primary care and schools. Key aspects of trauma-informed care are explored, including the role of the interdisciplinary team, screening processes and communication strategies that prioritize safety, trust and emotional support. Special considerations for paediatric, cognitively impaired and homeless populations are highlighted, as well as the importance of recognizing trauma in the absence of a formal post-traumatic stress disorder (PTSD) diagnosis. By integrating trauma-informed approaches, nurses can improve patient outcomes, reduce re-traumatization and foster a culture of care that respects the patient’s experiences.