Cassandra Fedele (c.1465–1558) was a Venetian humanist scholar whose career flourished during the late 1400s. Her extant work comprises a book of Latin letters to friends, scholars, and potential patrons, along with several orations. Fedele can be numbered among a small group of Italian women who were educated in the humanist curriculum, centered around the study of Classical Latin and Greek texts, which saw a rise in popularity in fourteenth-century Italy. Although preceded by women humanists such as Isotta Nogarola and her aunt Angela, Costanza Varano, and Battista Sforza, Fedele surpassed their fame, achieving widespread recognition in Italy and internationally.