Inflammatory bowel disease is a lifelong, chronic condition consisting of two main subtypes: ulcerative colitis (UC) and Crohn’s disease (CD). It is often characterized by an unpredictable disease course with fluctuating periods of quiescence and flares despite optimal therapy. Some individuals with IBD may develop disease-related gastrointestinal or extraintestinal complications. Delay in treatment may lead to potentially preventable complications and result in worse clinical outcomes. Driven by the aforementioned complexity, specialized IBD units consisting of a multidisciplinary team (MDT) have been established worldwide. The role of the IBD nurse within the MDT is discussed in this chapter.