Crohn’s disease can affect the bowel anywhere in the gastrointestinal tract, but most commonly affects the small bowel and perianal areas, where it may cause fistulae to form. Both enteric fistulae arising from the small bowel and perianal fistulae affecting the anorectum cause significant suffering for patients and are clinically difficult to treat. This chapter covers the manifestations and management options for fistulating Crohn’s disease.