Complementary and alternative medicine (CAM) is a broad spectrum of therapeutic and diagnostic practices that encompasses natural-based therapies including supplements, mind-body interventions, and whole medical systems such as acupuncture in addition to conventional medical management. Within the inflammatory bowel disease (IBD) population, there has been a shift to a more patient-centered shared decision-making approach that encompasses CAM therapies. This review examines the use of CAM therapy within the IBD patient population and some rationale behind its current growth. Specific therapies are then examined with available data behind its use within the ulcerative colitis (UC) and Crohn’s disease (CD) populations. The chapter further outlines the origins of these therapies and currently available recommendations and guidelines to use. Additional data is provided for alternative medical systems such as acupuncture and TCM as well as mind-body medicine examining a focused approach to lifestyle modifications and stress reduction. The use of CAM therapies with a focus on alternative therapies continues to grow and our understanding as a medical community is important to help bridge dialog between patients and providers. Increased knowledge and acceptance of CAM therapy will help offer a platform to discuss openly with patients and continue to build on the current limited research available.