Microarray analysis has emerged as a critical player in studying plant reactions to abiotic stress, providing comprehensive insights into the molecular mechanisms that underlie stress adaptation and tolerance. This chapter thoroughly examines microarray technology and its application in investigating plant reactions to diverse abiotic stressors, such as drought, salinity, extreme temperatures, and heavy metal toxicity. The paper delves into the experimental design, data analysis techniques, and interpretation of microarray findings, focusing on identifying stress-responsive genes, pathways, and regulatory networks. Furthermore, the chapter highlights the recent progress in microarray technology, particularly the rise of high-throughput sequencing-based transcriptomics, and its significance in comprehending plant stress responses on a genome-wide level. This technology, in your capable hands, has the potential to revolutionise agronomy and sustainable agriculture. Combining microarray data with other omics approaches and functional genomics tools, we can comprehensively understand the intricate molecular networks that control plant stress responses. This knowledge aids in creating crop varieties that are resistant to stress, a crucial step towards promoting sustainable agriculture.