Over 15% of the global population is disabled, therefore facing the resulting mobility challenges. In Ethiopia, many rely on inadequate mobility aids, highlighting the need for improved solutions for long-distance travel. To reduce such problems significantly, a detachable-handle electric wheelchair with a foldable, detachable, stretchable, and transferable feature is designed and developed based on Ethiopian anthropometry. Technical parameters for the design are selected based on QFD, the structures are modeled using SOLIDWORKS, and their load-carrying ability is analyzed using ANSYS. The detachable handle electric wheelchair is developed and tested on level road (zero roughness), old asphalt, and off-road conditions with the handle being attached and detached by different drivers of different weights. The test result is analyzed by Design expert-13 using two-way ANOVA. As the roughness of the road increases from smooth road (0) to poor road (rough terrain (1)), then the wheelchair speed is reduced from 5.8 m/s to 4 m/s, 5.5 m/s to 3.5 m/s, and 5.2 m/s to 3 m/s when it is driven respectively by a 45-kg, 57-kg, and 70-kg user. In terms of speed, the attached-handle wheelchair is 1.2 m/s and 2 m/s higher than detached-handle wheelchairs respectively on smooth asphalt and old asphalt or off-road driving respectively. Regarding inclination, the attached-handle electric wheelchair can climb up to 17°, whereas the detached handle climbs up to 10°, which shows 60% higher climbing performance compared to the standard one.