5S method has been applied in Higher Education Institutions (HEIs) abroad to eliminate waste and improve working conditions. Many workshops and laboratories in Moroccan higher technical education institutions (HTEIs) are characterized by the presence of bad working conditions and waste because of the bad organization of workplace, but there is no HEI that has applied this method to solve this problem. The aim of this paper is to emphasize the importance of applying 5S method in HEIs. To achieve this objective, a structured 9-step approach was used, which takes into account the obstacles to implementing Lean Higher Education (LHE) before applying 5S. A case study is carried out on an automotive workshop in a HTEI in Morocco. The results show improvements in working conditions, safety and the quality of teaching-learning. In addition, a decrease in time needed to find materials, tools and documents. This time is considered a time of non-value-added in the teaching-learning process (waste of waiting and motion). HEIs that want to improve activities in workshops, laboratories and teaching-learning process can simply follow the steps presented in this paper and make teaching-learning and research work more efficient. This research is the first of its kind of the application of 5S in Moroccan HEIs. Lean tools in higher education can benefit both faculty and students (teaching-learning process).