This chapter compares two models for evaluating trade-offs between morbidity and mortality: the Quality-Adjusted Life Year (QALY) model and the Load model. QALYs assess the trade-off between quality of life and life expectancy, using a single value to represent health outcomes. Conversely, the Load model evaluates the combined burden of illness and death over time, considering death as an event and illness as a state. A hypothetical lifetime example reveals that QALYs minimize the impact of illness to be only 1% of the total burden, while the Load model assigns equal weight to both illness and death. This stark 50-fold difference underscores significant implications for healthcare policy. Although widely accepted, the QALY model faces criticisms for misalignments with real-world preferences. The Load model offers a more intuitive approach but requires further empirical validation to support broader implementation in healthcare decision-making.