Autoimmune disorders, affecting approximately 10% of the population, are the third most common type of disorder in the United States. These disorders cause the body’s immune system to mistakenly attack its own healthy tissues, which can affect a single organ or multiple organ systems (Cornelius, 2019). Women are significantly more likely to develop autoimmune disease, representing 64% of individuals diagnosed between 2000 and 2019. This translates to a 13% prevalence among women compared to 7% in men (Angum et al., 2020). Table 9.1 provides a summary of gender differences in prevalence for each of the autoimmune conditions discussed in this chapter.