The use of innovative technology solutions in healthcare is not without challenges. This chapter will provide insight to these challenges that developers and users of such technologies might face and how these can be changed into opportunities. Scientists, clinicians, and educators are just beginning to scratch the surface when it comes to current applications of technology in the healthcare context for the management of the disease. Historically, these technologies have been expensive, available to few and mostly sought out by researchers and specialized technicians. These technologies have been integrated into a variety of healthcare settings for routine painful medical procedures, physical therapy, pain rehabilitation, chronic pain management, and to treat a variety of psychiatric conditions (i.e., anxiety, post-traumatic stress disorder), to name a few but on the horizon, there are new areas and possibilities opened up for such technologies (e.g., advanced cancer screening through machine learning). While new opportunities are opening up, there are challenges that still remain with a significant one being the regulatory frameworks for such technologies.