Climate change exacerbates the prevalence and severity of mango diseases due to rising temperatures, erratic rainfall, and humidity fluctuations, creating conducive environments for pathogenic outbreaks. Traditional disease management strategies, such as chemical fungicides, face limitations due to environmental concerns and resistance development. Nanotechnology offers a promising solution for managing mango diseases effectively and sustainably under these changing conditions. Nanoparticles, such as silver, copper, and zinc-based formulations, exhibit antimicrobial properties that target a wide range of pathogens while minimizing the ecological footprint. Their small size allows for better penetration and controlled release, enhancing their efficacy and reducing the quantity required. Recent studies have demonstrated the potential of nanoparticles in suppressing fungal pathogens like Colletotrichum gloeosporioides and Lasiodiplodia theobromae, which cause devastating diseases like anthracnose and stem-end rot. Additionally, nanoparticle applications can be integrated with existing disease management practices, such as resistant cultivars and biocontrol agents, to provide a holistic approach. This chapter explores the role of nanoparticles in mitigating mango diseases in the context of climate change, highlighting their mechanisms, efficacy, and environmental safety. By embracing nanotechnology, mango cultivation can achieve enhanced disease resistance and sustainable productivity amidst the challenges posed by global climate shifts.