Climate change, driven by human activities, is causing global impacts like temperature increases, greenhouse gases, air pollutants, altered solar radiation, UV-B, and changes in precipitation patterns. These changes lead to more frequent droughts, uneven temperature, salinity, and heavy metal, significantly affecting agriculture by reducing crop yields and quality, which has major socio-economic implications. Such abiotic stresses adversely affect plant growth, development, and metabolic activities, consequently reducing crop yields and quality. With the future climate changes being unpredictable, it is crucial to modify existing agricultural practices to cope with these changes. Abiotic stresses can modify plant metabolism, either inhibiting or enhancing the production of secondary metabolites. While the essential roles of these compounds in plant adaptation and defense are recognized, their reaction to climate change remains largely unexplored. As climate change impacts intensify, understanding the regulatory effects on plant secondary metabolism is becoming more critical. Research continues on how individual climate change factors like high temperatures, increased salinity levels, drought, and elevated ultraviolet-B radiation, along with their combined effects, influence secondary metabolites such as phenolics, flavonoids, terpenes, alkaloids, etc. of mango plants. It is vital to grasp how these secondary metabolites contribute to the resilience of certain plants under future conditions. The book chapter aims to compile recent research on how climate change impacts the secondary metabolism of plants, particularly mangoes. It discusses the variations in compound concentrations caused by climate factors, providing essential insights into plant responses and performance under changing environmental conditions.