Orthotropic bone remodeling algorithm coupled with finite element models have been used extensively in bone adaptation studies in order to prognosticate the elastic material property distribution across human femur bone subjected to multiple routine activities. Peri-prosthetic bone resorption following a hip replacement surgery owing to post-operative bone remodeling in response to altered bio-mechanical environment around hip stem, may result in failure of prosthesis. Various numerical models have included a ‘lazy zone’ with no remodeling response to mechanical stimulus. Thus, for bio-mechanical simulations related to bone adaptation the selection of extent of lazy zone threshold is of crucial importance. This pre-clinical in silico study addresses the effect of size of lazy zone on orthotropic bone adaptation in an implanted femur post-surgery simulated with different physiological loading. In order to assess their impact on bone remodeling and material property distribution across implanted femur, this study incorporates eight distinct lazy zone thresholds (70, 60, 40, …, 10% and without lazy zone). It was observed that parametric variation in the size of lazy zone significantly affected bone remodeling stimulus. Decrease in lazy zone threshold was followed by elevated level of bone loss around hip stem, where an increase in threshold inhibited resorption. Regardless little noticeable agreement in elastic property distribution near cortex, the assessable differences in trabecular density patterns emphasizes the effects of the lazy zone on the orthotropic bone adaptation. A deeper understanding of these dynamics enables more precise predictions of bone behavior after surgery, helping to shape rehabilitation strategies.