The successful transition to sustainable and competitive automotive production necessitates the identification and implementation of radically new technologies. The implementation of innovations in manufacturing is a challenging process, as the maturity of technology and employee acceptance are critical factors for project success. A conceptual framework is designed based on a top-down and bottom-up research approach, considering manufacturing requirements and characteristics in order to derive implementation strategies. Assessment criteria are identified which consider technology as well as employee readiness for manufacturing changes. This is achieved by applying a questionnaire approach with guiding questions. The resulting conceptual Manufacturing Technology Implementation Framework (MTI) supports manufacturing companies in planning radical technological implementation projects, evaluating the current status, deriving open issues and developing promising implementation strategies.