As the second-largest contributor to global carbon emissions, the high-end fashion and textile sector is under mounting pressure to embrace eco-friendly practices. This chapter explores how green chemistry and sustainable methods can minimize the ecological footprint of high-end textile manufacturing. Green chemistry principles, including waste reduction, efficient atom utilization, safer synthesis methods, and biodegradable product design, provide a supplementary approach to eco-friendly technologies to minimize the ecological consequences of industrial activities. The utilization of environment-friendly raw materials, catalysis, and real-time analysis for pollution prevention are also discussed. It also highlights the importance of textile fibres, particularly natural fibres, in garment production and the need for sustainable raw materials. The ecological impacts of textile manufacturing and consumption are substantial, and textile production requires significant resources and contributes significantly to industrial water pollution. Consumer use also significantly contributes to clothing lifecycle emissions, with current clothing purchases quadrupling compared to those two decades ago. The adoption of sustainable practices in the luxury sector is crucial, as the diminishing value of luxury brands and increasing consumer preference for sustainable goods necessitate change. Evolving technologies have the ability to facilitate sustainable transitions in luxury fashion, and the textile industry acknowledges the importance of green chemistry principles in addressing the environmental impacts of conventional production methods.