This work arose from an interest in exploring the topic of social benefit-driven organizations, with application in health, appreciating how research has been carried out in this field. It also aims to present the Portuguese experience in this area, specifically in the context of “Portugal—Inovação Social”, a public initiative to promote and support social innovation in Portugal. A scoping review was carried out to identify and map evidence on this area, namely the focus of analysis, main actors, and regions under study. The results reveal, firstly, that most of the research in this field is not business-oriented and that there are few primary studies, which may reflect insufficient research around this issue, particularly into its application. As for the actors involved in collaboration with health, there seems to be a predominance of actors in the social area. Concerning the regions under study, the United Kingdom is dominant. Regarding Portuguese experience, projects labelled as “health” are mainly provided by the social sector and, although financing shows private companies’ involvement, concrete action is still needed.