Medical imaging technology use has grown substantially throughout the world, even in low-resource regions, where it was historically unavailable. Various informatics platforms and technologies play an important role in bridging the gap between low- and high-resource settings in the accessibility of imaging services. Picture archiving and communication system (PACS) platforms have served as a tool that can provide tremendous benefits in low- and middle-income countries (LMICs). Continual improvements in network infrastructure, declining hardware costs, and adoption of cloud technologies will also make the development of sustainable imaging network solutions easier in the future.