To manage the O2 supply in patients who need improvement in O2 saturation, extracorporeal membrane oxygenation (ECMO) is alternatively applied. In general, a serial connection of a blood pump with an artificial lung is used to supply oxygen to the vessel. Recently, extracorporeal carbon di-oxide removal (ECCO2R) has the potential to play a role in the recovery of acute respiratory distress patients. This study aimed to establish a new cannula design for effectively managing oxygenation and carbon dioxide removal with a simple structure. In this study, we composed a membrane oxygenation system equipped with a double luminal cannula with an axial rotary blood pump actuator and its design. The cannula is designed as an intravenous cannulation technique to achieve assistive oxygenation in the vena cava via a single-port approach. Once the cannula is inserted transcutaneous via the femoral or jugular vein towards the right atrium via superior or inferior vena cava, respectively, an intra-cannula blood pump delivers blood from the distal portion into the proximal vein via the mem-brane oxygenation layer of the cannula. In this study, we made a prototype of the cannula with a small axial blood pump and examined its design feasibility as proof of concept.