Trauma in the setting of a pandemic requires an approach similar to that of disaster management. The difference between a pandemic and a natural disaster or bioterrorism is that a pandemic has an uncertain endpoint. Furthermore, with a new disease, particularly one on a global scale, there is a constant generation of new information for its prevention, diagnosis, and treatment. As such, the situation on a local, regional, and global scale is constantly evolving and changing. In order to maintain trauma readiness and the highest possible level of care for trauma patients during a pandemic, four categories must be addressed to meet evolving demands: staff, stuff, space, and systems.