In optogenetics, light-sensitive proteins introduced into specific cells can only be activated by light of specific wavelengths. Therefore, it is possible to precisely modulate the functionality of neural cells by activating or inhibiting ion channels with light of the corresponding wavelength. Experimental setups often require electrodes or optical fibers implanted on or in the brains of animals. Wired connections between the animal’s head and the equipment can pose some challenges to the experiment. In this study, we compared wired optogenetic control systems with battery-powered wireless optogenetic control systems. We found that the wired optogenetic control system outperformed the battery-powered wireless system in terms of both the impact on the natural behavior of the experimental subjects and the efficiency of optogenetic control. We also proposed some improvements in both aspects.