Knowledge of past literature is a huge help in avoiding present mistakes. Historically, core topics of international business research have attracted a critical mass of researchers. These include (1) the explanation of foreign direct investment flows, (2) theoretical conceptions of evolution of multinational enterprises, (3) the transition from internationalization to globalization including joint ventures and alliances, (4) explaining the emergence and strategies of MNEs from emerging economies, (5) exploring the growth, causes, and consequences of offshoring and the disaggregation of global value chains, (6) understanding how MNEs respond to greater pressures for social responsibility and sustainability. Current global “Grand Challenges” are phenomena-driven, requiring interdisciplinary perspectives, spanning multiple levels of analysis, and involve interactions among business, government, and civil society globally. IB scholars are uniquely well endowed to progress solutions to the pressing Grand Challenges of climate change, pandemics, migration, global poverty, transnational crime, and terrorism. All these issues are only understandable and resolvable at a global level. Tackling them can be informed by IB history.