Cork wastes issued from factories were considered the main factor affecting environmental pollution. In this respect, an eco-friendly design based on bio-recycling and recovery of agglomerate cork waste from an aggregate to manufacture a bio-based material is proposed. The novel designed sample is intended for panel usage as facades and separation walls of civil engineering structures, allowing thus the improvement of the mechanical and thermal features. Indeed, the present work aims to experimentally and numerically study the axial behavior of samples with standard dimensions based on plaster reinforced and lightened by additions of cork waste. The cork waste treated and crushed with a specific particle size was randomly arranged along the height of the specimens. The manufactured samples tested under axial compression were also modeled using nonlinear finite element structural analysis. The overall behavior of tested and simulated members was satisfactory comparable to the experimental results reported in the literature, and manifested excellent thermal properties, affirming the effectiveness of the designed building material. The obtained test and simulation outcomes provide the positive influence of cork addition on the rupture modes of the newly designed samples to respond to the criteria of environmental requirements.