The creative incorporation of machine learning predictive models into blockchain frameworks appears as a game-changing approach for augmenting fault tolerance and increasing operational resilience in the dynamic environment of supply chain management. The potential, results, and implications of the integration are examined in this paper, providing a holistic perspective on its effect on contemporary supply networks. The essay starts by discussing the ever-changing difficulties encountered by supply chain networks operating in the modern global economy. Fault tolerance in the supply chain is becoming a pressing issue, calling for creative solutions to minimize interruptions and maximize efficiency. The importance of using machine learning predictive models into blockchain frameworks is outlined in the introduction, which also provides context for the rest of the paper. Methods used to test the integration's usefulness are described in the research paper. Logical regression, random forests, CNNs, SVMs, and LSTM models are all part of this category of cutting-edge machine learning methods. Machine learning algorithms in blockchain frameworks may protect supply networks from catastrophic breakdowns. The suggested strategy beats conventional models in accuracy (92%), precision (88%), recall (93%), F1-Score (90%), MAE (0.12), and MSE (0.15). The recommended method has a higher MSE than traditional models. The findings suggest that supply chain networks anticipate future occurrences and identify issues better.As a result, businesses will be able to prevent and correct problems like shipment delays and stock-outs. The danger of data tampering and fraudulent activities has also been reduced thanks to the use of blockchain technology, which has improved data integrity and trust among supply chain players. This impact is shown by a 30% decrease in data tampering events inside the supply chain. The revolutionary potential of the novel integration of machine learning prediction models inside blockchain frameworks is emphasized throughout the study's final section. Because of its capacity to improve predictions, data security, and procedures, supply chain management may evolve. This shift might happen soon. Aside from adoption challenges such as data quality, security infrastructure, and compliance, the adaptability and flexibility of integration make it critical for robust and successful supply chain ecosystems. Despite several hurdles, this integration provides organisations with the tools they need to thrive and adapt in today's fast-paced, internationally competitive market.