After its initial documentation in Anopheles mosquitoes during the 1950s, insecticide resistance has rapidly proliferated across most sub-Saharan African nations endemic to malaria. This escalation undermines the efficiency of vector control initiatives, potentially causing a rebound in malaria cases. Principally driven by four techniques (behavioral adaption, receptor site adaption, metabolic adaption, and cuticular adaption), the occurrence correlates with integral alterations in adaptive insect vectors that might impact the growth of infiltrating Plasmodium organisms. An extensive literature review was performed utilizing the PubMed database to discover studies cognate to insecticide-resistant malaria vectors. The search focused on five main areas: (A) the presence of Plasmodium infection in malaria carriers that are immune to insecticides; (B) the sialome of these vectors; (C) the impact of pesticide tolerance on the defense of malaria-carrying insects; (D) the microbial of these carriers and infections; and (E) the fitness disadvantage of insect repellent tolerance in malaria vectors. The study was conducted between January and April 2024, without any limitations on the publication date. Initially, a total of 560 articles were retrieved. Articles that did not specifically address insecticide resistance in Anopheles mosquitoes in relation to Plasmodium infestation, vector efficacy, salivary components, or lifespan were excluded. Ultimately, 30 studies that met these aforementioned criteria were selected for inclusion in the review. While global evidence remains contradictory, there appears to be an increased permissiveness to Plasmodium infections among insecticide-resistant vectors. However, the current understanding of key factors influencing vector competence, particularly immunity and microbiota communities within specific parts of insecticide-resistant vectors such as the gut, mouthparts, and exocuticle is still inadequate. This limits our ability to definitively assess the epidemiological importance of these resistant vectors in relation to their prone counterparts. Additional studies are essential to resolve major knowledge deficiencies, particularly in comprehending how the preference and dissemination of pesticide-resistant mosquito populations could impact malaria epidemiology. While there are observations in the current literature suggesting potential future trends, comprehensive predictive models have not yet been developed.